Table 2.
Variables | No. of studies | Codominant model: TC vs. TT | Codominant model: CC vs. TT | Dominant model: TC + CC vs. TT | Recessive model: CC vs. TC+TT | Allele: C vs. T | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | P value | I2 (%) | OR (95%CI) | P value | I2 (%) | OR (95%CI) | P value | I2 (%) | OR (95%CI) | P value | I2 (%) | OR (95%CI) | P value | I2 (%) | ||
All cancers | 11 | 1.10 (1.02, 1.19) | 0.009 | 34 | 1.06 (0.85, 1.33) | 0.6 | 69 | 1.12 (1.00, 1.26) | 0.06 | 59 | 0.99 (0.82, 1.20) | 0.91 | 59 | 1.07 (0.97, 1.19) | 0.18 | 70 |
Cancer type | ||||||||||||||||
Digestive tract cancer | 6 | 1.10 (0.99, 1.22) | 0.07 | 42 | 0.90 (0.67, 1.20) | 0.46 | 61 | 1.07 (0.91, 1.26) | 0.39 | 60 | 0.87 (0.74, 1.03) | 0.1 | 47 | 1.01 (0.88, 1.16) | 0.88 | 67 |
Breast cancer | 2 | 1.04 (0.91, 1.20) | 0.55 | 40 | 0.87 (0.70, 1.08) | 0.21 | 6 | 1.02 (0.84, 1.25) | 0.84 | 55 | 0.86 (0.70, 1.05) | 0.14 | 0 | 0.98 (0.84, 1.15) | 0.83 | 58 |
Nasopharyngeal carcinoma | 1 | 1.37 (0.96, 1.98) | 0.09 | / | 1.72 (0.99, 2.96) | 0.05 | / | 1.44 (1.02, 2.03) | 0.04 | / | 1.45 (0.87, 2.42) | 0.15 | / | 1.33 (1.04, 1.70) | 0.03 | / |
Osteosarcoma | 1 | 1.77 (1.03, 3.03) | 0.04 | / | 2.52 (1.25, 5.10) | 0.01 | / | 1.96 (1.19, 3.24) | 0.009 | / | 1.86 (0.98, 3.54) | 0.06 | / | 1.68 (1.19, 2.39) | 0.004 | / |
Renal cell cancer | 1 | 1.10 (0.88, 1.36) | 0.4 | / | 1.53 (1.07, 2.19) | 0.02 | / | 1.17 (0.95, 1.43) | 0.15 | / | 1.46 (1.04, 2.06) | 0.03 | / | 1.18 (1.01, 1.37) | 0.04 | / |
Ethnicity | ||||||||||||||||
Asian | 9 | 1.13 (1.03, 1.24) | 0.007 | 37 | 1.12 (0.84, 1.49) | 0.44 | 72 | 1.16 (1.00, 1.33) | 0.05 | 61 | 1.03 (0.81, 1.31) | 0.83 | 64 | 1.10 (0.97, 1.25) | 0.14 | 72 |
Caucasian | 1 | 0.97 (0.81, 1.16) | 0.74 | / | 0.81 (0.62, 1.05) | 0.1 | / | 0.93 (0.79, 1.10) | 0.41 | / | 0.82 (0.64, 1.04) | 0.11 | / | 0.92 (0.81, 1.04) | 0.16 | / |
African American | 1 | 1.17 (0.94, 1.46) | 0.17 | / | 1.03 (0.70, 1.51) | 0.88 | / | 1.14 (0.93, 1.41) | 0.21 | / | 0.96 (0.66, 1.39) | 0.83 | / | 1.08 (0.91, 1.27) | 0.38 | / |