Table 1C.

Correlated mutation sets include the core and surface residues in group 5.

GROUP 5 POSITIONS	CORE AND SURFACE RESIDUES CORE		SURFACES
6	Val-7		Gin-130 Thr-74	Gly-179 Asn-62
70			Asn-193 Thr-74 Lys-71 Leu-24	Gin-130 Ala-72 Ala-57
79	Val-80	Val-69	Ala-202 Glu-108 Ala-72 Asp-47	Gin-130 Thr-74 Pro-63 Lys-31
105	Thr-178	Ala-220	Glu-226 Asp-211 Asp-194 Lys-128 He-106 Thr-74 Gly-50 Ser-46 Arg-28	Arg-213 Ala-206 Gin-130 Met-126 Met-96 Thr-61 Tyr-48 Glu-39 Glu-4
148	Gly-79		Ala-202 GLn-130 Thr-74	Ala-149 Glu-108 Gln-43
157	Val-158		Asn-193 Gin-130 Ala-72	Lys-190 Thr-174
173	Val-174	Ala-57	Pro-212 Thr-74 Leu-24	Gly-79 Ala-72
194			Thr-74 Ser-104 Glu-195	Gly-79 Gin-130 Ile-244

Notes: (A) It displays the core residues identified by the Talana program. The residues in each group are located at the core of the protein structure. The occurrences of valine and isoleucine are more frequent compared to other amino acids, showing that these hydrophobic amino acids potentially play a more vital role in stabilizing the chemical structure of the proteins. (B) It displays the surface residues identified using Talana. These residues are located on the surface of protein structures and are distant from each other. (C) It shows the identification of correlated mutation sets and their core and surface characteristics for group 5.