Table 3.
NAME | NUMBER OF AMINO ACIDS | DESCRIPTION | INTENDED USE | COMPANY | TRIAL PHASE |
---|---|---|---|---|---|
Omiganan (MBI-226, MX-226, CSL-001) | 12 | Synthetic analog of indolicidin | Topical antiseptic prevention of catheter infection, severe acne and rosacea | Migenix/BioWest therapeutics Cutanea Life Sciences | III/II |
Pexiganan (MSI-78) | 22 | Synthetic analog of magainin 2 | Topical antibiotic – diabetic ulcers | Macrochem | III |
Iseganan (IB-367) | 17 | Protegrin 1 derivative | Prevention of oral mucositis | Ardea Biosciences | III |
LTX-109 | 3 | Peptidomimetic | Topical antibiotic | Lytic Biopharma | I/II |
hLF1–11 | 11 | Lactoferrin derivative | Prevention of bacteraemia and fungal infections | AM Pharma | I/II |
OP-145 | 24 | LL-37 derivative | Treatment of chronic middle ear infection | Octoplus | I/II |