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. Author manuscript; available in PMC: 2015 Dec 3.
Published in final edited form as: Neuroreport. 2014 Dec 3;25(17):1331–1337. doi: 10.1097/WNR.0000000000000268

Figure 3. Antidepressants fluoxetine and imipramine prevent NIFAR.

Figure 3

Hippocampal neurons were pre-incubated with drugs for the indicated times prior to addition of 50 μM NMDA for 5 min. Data are expressed as the percentage of neurons exhibiting NIFAR and graphed as mean ± SEM. (**p<0.01, ***p<0.001 one-way ANOVA followed by Bonferroni post hoc test, comparing all groups versus NMDA alone; number of coverslips: 6 per condition in for fluoxetine, 12 per condition for imipramine; number of neurons counted per coverslip = 400–800). (a) Hippocampal neurons were pre-incubated with 10μM fluoxetine for the indicated times prior to addition of 50 μM NMDA for 5 min. (b) Hippocampal neurons were pre-incubated with 20μM imipramine for the indicated times prior to addition of 50 μM NMDA for 5 min.