Table 3.
Clusters showing significant differences in participants with bipolar I disorder (BP-I) versus participants with major depressive disorder (MDD) during emotional images (emotional) and circles (attentional)
| Region of interest | Laterality | Center of mass Talairach coordinates |
Volume (3-mm3 voxels) | Greater activation in | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| BP-I versus MDD emotional | ||||||
| Lingual gyrus, cuneus, middle occipital gyrus, middle temporal gyrus | L | +22.5 | +97.5 | –15.5 | 616 | MDD |
| Cuneus, middle occipital gyrus, middle temporal gyrus | R | –19.5 | +100.5 | +8.5 | 603 | MDD |
| Lingual gyrus, middle occipital gyrus, posterior cingulate gyrus, parahippocampal gyrus | L | +25.5 | +97.5 | +5.5 | 69 | BP-I |
| Precuneus | R | –4.5 | +61.5 | +65.5 | 66 | BP-I |
| Inferior frontal gyrus, precentral gyrus | R | –37.5 | –4.5 | +29.5 | 60 | MDD |
| Inferior parietal lobule | R | –49.5 | +61.5 | +47.5 | 50 | BP-I |
| BP-I versus MDD attentional | ||||||
| Inferior parietal lobule | L | +52.5 | +34.5 | +53.5 | 295 | MDD |
| Parahippocampal gyrus, culmen | R | –13.5 | +28.5 | –12.5 | 65 | MDD |
| Parahippocampal gyrus, cerebellum | L | +13.5 | +28.5 | –18.5 | 61 | MDD |
| Inferior parietal lobule | L | +40.5 | +55.5 | +47.5 | 57 | MDD |
| Medial frontal gyrus | L | +7.5 | +13.5 | +53.5 | 48 | MDD |
| Postcentral gyrus, inferior parietal lobule | L | +58.5 | +19.5 | +29.5 | 40 | MDD |
Significant at p = 0.05 at threshold p = 0.005 at cluster threshold of 37. L = left; R = right.