Table 5.
Clusters showing significant differences in participants with major depressive disorder (MDD) versus healthy comparison (HC) participants during emotional images
| Region of interest | Laterality | Center of mass Talairach coordinates |
Volume (3-mm3 voxels) | Greater activation in | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Declive | R | −40.5 | +61.5 | −21.5 | 200 | HC |
| Superior temporal gyrus | L | +58.5 | +7.5 | +2.5 | 196 | MDD |
| Insula | R | −37.5 | −13.5 | −0.5 | 185 | MDD |
| Cingulate gyrus | R | −1.5 | +22.5 | +20.5 | 157 | MDD |
| Middle temporal gyrus | R | −61.5 | −1.5 | −9.5 | 132 | HC |
| Lingual gyrus | L | +22.5 | +97.5 | −15.5 | 76 | MDD |
| Parahippocampal gyrus | L | +16.5 | +19.5 | −24.5 | 66 | MDD |
| Middle temporal gyrus | R | −43.5 | +82.5 | +20.5 | 62 | MDD |
| Middle frontal gyrus | R | −25.5 | −31.5 | −15.5 | 42 | HC |
| Superior frontal gyrus | L | +1.5 | −7.5 | +50.5 | 42 | MDD |
| Culmen | R | −25.5 | +49.5 | −24.5 | 40 | MDD |
Significant at p = 0.05 at threshold p = 0.005 at cluster threshold of 37. R = right; L = left.