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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Dig Dis Sci. 2014 Jun 13;59(11):2757–2764. doi: 10.1007/s10620-014-3245-9

Fig. 1.

Fig. 1

Histologic features of advanced adenomas and MMR immu-nohistochemistry. a Typical adenoma (2009 magnification, H&E stain). b Adenoma in another patient with high-grade dysplasia displaying loss of nuclear polarity and cribriform gland architecture (400× magnification, H&E stain). c Loss of MLH1 nuclear positivity (200× magnification, IHC) in the 19-year-old female subject from this study. Note the positive control example of retained MLH1 (inset) in a different subject. d Loss of PMS2 nuclear positivity in the same 19-year-old female subject as panel C (200× magnification, IHC). Note the positive control example of retained PMS2 in a different subject (inset)