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. 2014 Jun 9;18(11):2165–2175. doi: 10.1111/jcmm.12326

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inhibition of dynein activity blocked lysosome fusion. (A) Representative confocal microscopic images showing the co-localization of LC3B-GFP with Lamp1-RFP in live CAMs. (B) Summarized co-localization coefficient (PCC) of LC3B and Lamp1 in CAMs transfected with scramble or DCTN2 cDNA. (C) Summarized co-localization coefficient of LC3B-GFP and Lamp1-RFP in CAMs with or without EHNA (30 μM; n = 6 for all panels). *P < 0.05 versus Ctrl or Scramble; ^#P < 0.05 versus CAMs treated with X/XO or H₂O₂ or Nox1 cDNA transfection alone.