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. 2014 Jun 9;18(11):2165–2175. doi: 10.1111/jcmm.12326

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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NAADP-lysosome Ca²⁺-controlled high glucose–induced dynein activation. (A) Summarized data showing the effects of Nox1 inhibitor ML117 (100 μM) on O₂⁻ production in CAMs under control and high glucose (30 mM) for 48 hrs. Summarized data showing the effects of Nox1 inhibitor ML117, dynein inhibitor EHNA and NAADP antagonists PPADS or NED-19 on dynein ATPase activity (B) or APLs formation (red-to-green fluorescence ratio of acridine orange; C) in CAMs under resting control condition or with high glucose (n = 6 for all panels). *P < 0.05 versus Ctrl; ^#P < 0.05 versus CAMs treated with high glucose.