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. 2014 Sep 5;28(11):1866–1874. doi: 10.1210/me.2014-1204

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Copyright © 2014 by the Endocrine Society

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Figure 1. — Genetic ablation of Tph1 gene in mice decreased circulating and mammary gland 5-HT levels. WT mouse dams were given saline and Tph1^−/− dams were given either saline or daily injections of exogenous 5-HTP [100 mg/kg; Tph1^−/−(5-HTP)], from pregnancy day 13 to lactation day 10. A, Serum 5-HT concentration determined on day 1, day 5, and day 10 of lactation. B, Mammary 5-HT protein concentration determined on day 10 of lactation. All values are means ± SEM (n = 7 per group). *, P < .05; **, P < 0.01; ***, P < .001.