Table 1.
Radioactivity concentration in plasma after single oral or intravenous administration of 14C hyaluronic acid to rats (dose: p.o.; 25 mg/kg, IV; 10 mg/kg).
| Time | Radioactivity concentration | |
|---|---|---|
| (μg eq. of hyaluronic acid/mL) | ||
| p.o. | i.v. | |
| 5 min | N.D. | 233.0 ± 22.1 |
| 15 | N.D. | 222.5 ± 15.7 |
| 30 | N.D. | 211.7 ± 8.4 |
| 1 hr | N.D. | 180.1 ± 2.6 |
| 2 | N.D. | 123.1 ± 2.0 |
| 4 | 1.1 ± 0.8 | 47.8 ± 9.4 |
| 8 | 7.6 ± 0.6 | 3.6 ± 0.3 |
| 24 | 3.5 ± 0.3 | 1.7 ± 0.1 |
| 48 | 2.0 ± 0.1 | 0.9 ± 0.1 |
| 72 | 1.3 ± 0.1 | 0.6 ± 0.1 |
| 96 | 0.9 ± 0.0 | 0.4 ± 0.1 |
| 120 | 0.7 ± 0.1 | 0.3 ± 0.0 |
| 144 | 0.5 ± 0.0 | 0.2 ± 0.0 |
| 168 | 0.4 ± 0.1 | 0.1 ± 0.1 |
|
| ||
| Detection limit | 0.1 | 0.1 |
|
| ||
| T max (hr) | 8 ± 0 | — |
|
| ||
| C max (μg eq./mL) | 7.6 ± 0.6 | — |
|
| ||
| C 0 (μg eq./mL) | — | 238.4 ± 25.5 |
|
| ||
| T 1/2 | ||
| (5 min–8 hr) (hr) | — | 1.3 ± 0.1 |
| (24–168 hr) (day) | 1.9 ± 0.1 | 1.7 ± 0.1 |
|
| ||
| AUC (μg eq.·hr/mL) | ||
| (0–168 hr) | 284 ± 16 | 757 ± 37 |
| (0–∞) | 309 ± 20 | 765 ± 40 |
Data are expressed as the mean values ± S.D. of three animals.
N.D.: not detected.
—: not determined.