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. 2014 Oct 14;12:42. doi: 10.1186/s12951-014-0042-8

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© Thakur et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TEM micrograph of Sertoli cell, lysosome and Cytoplasm. (a) Sertoli cell cytoplasm of control group 1 showing healthy cytoplasm having intact germ cells (Gs) and intact granular cytoplasm (Cy). Scale bar =0.5 μm, (b) Sertoli cell ultra structure showing degenerated cytoplasm (Cy) and lysosome bound nanoparticles (L). Scale bar =0.5 μm, (c) Highly vacuolated (V) sertoli cell cytoplasm in nanoparticle treated group. Scale bar =0.5 μm and (d) Sertoli cell cytoplasm in treated group 2 showing accumulation (*) of nanoparticles and liposomes containing nanoparticles (L). Scale bar =0.5 μm.