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. 2014 Oct 14;6(10):81. doi: 10.1186/s13073-014-0081-7

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© Vuong et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Computational workflow and general summary. (A) The protein pocket-based integrative analysis workflow. (B) The distribution of protein pocket mutations by mutation types. (C) The number of missense mutations in the pocket regions of the top 10 frequently mutated genes. (D) Distribution of the number of missense mutations in the pocket regions in 28 cancer types. The detailed data are provided in Additional file 1: Table S1.