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. 2014 Oct 14;6(10):81. doi: 10.1186/s13073-014-0081-7

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© Vuong et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The enrichment analyses of genes harboring pocket mutations in cancer genes and a co-expressed protein interaction network (CePIN). (A) Venn diagram of genes harboring pocket mutations, cancer driver genes, and Cancer Gene Census (CGC) genes. (B) Genes harboring pocket mutations were enriched in cancer driver genes. (C) Genes harboring pocket mutations were enriched in CGC genes. (D) Genes harboring pocket mutations were enriched in cancer-associated genes. (E) Genes harboring pocket mutations tended to be highly co-expressed in CePIN. The P value was calculated using Fisher’s exact test. The detailed data regarding statistical analysis are provided in Additional file 4: Table S3 and Additional file 5: Table S4.