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. 2014 Oct 14;6(10):81. doi: 10.1186/s13073-014-0081-7

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© Vuong et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Anticancer drug sensitivity analysis. (A) The two-dimensional chemical structures of three anticancer drugs: midostaurin, vinorelbine, and tipifarnib. (B) The distribution of the half maximal inhibitory concentration (IC₅₀, natural log scale) values for BAX gene-mutated cancer cell lines (BAX-mut) versus BAX gene wild-type cancer cell lines (BAX-WT) using all of the BAX gene’s mutation profiles. (C) The distribution of (IC₅₀, natural log scale) values for BAX pocket mutated cancer cell lines (BAX-Pmut) versus BAX wild-type cancer cell lines (BAX-WT) using BAX protein pocket mutations only. The P values were calculated by the Wilcoxon test.