Table 1.

The effect of pathogen-mediated selection and disassortative mating on allelic richness of MHC loci (n = 100 simulations; mean ±95% CI).

random mating
pathogen mutation rate	Ne	50	100	500	1000	5000	10 000
no pathogens		1.00 ± 0.00	1.01 ± 0.00	1.08 ± 0.03	1.18 ± 0.06	4.29 ± 0.22	8.27 ± 0.32
10−3		1.05 ± 0.02	1.17 ± 0.05	2.48 ± 0.09	3.69 ± 0.14	11.78 ± 0.25	23.72 ± 0.55
2 × 10−3		1.06 ± 0.04	1.24 ± 0.07	4.75 ± 0.24	10.23 ± 0.16	28.38 ± 0.52	43.44 ± 0.68
5 × 10−3		1.33 ± 0.08	2.21 ± 0.15	15.69 ± 0.33	26.60 ± 0.43	54.85 ± 0.55	88.00 ± 0.64

soft disassortative mating (h = 0)
pathogen mutation rate	Ne	50	100	500	1000	5000	10 000
no pathogens		2.90 ± 0.06	3.04 ± 0.02	4.44 ± 0.10	5.55 ± 0.12	10.55 ± 0.19	15.07 ± 0.32
10−3		1.41 ± 0.10	2.52 ± 0.08	4.72 ± 0.18	7.08 ± 0.39	13.87 ± 0.32	26.20 ± 0.53
2 × 10−3		1.94 ± 0.09	2.80 ± 0.09	8.53 ± 0.29	15.63 ± 0.53	30.74 ± 0.46	46.96 ± 0.63
5 × 10−3		2.40 ± 0.09	3.96 ± 0.13	17.30 ± 0.26	27.90 ± 0.36	56.23 ± 0.47	88.05 ± 0.62

hard disassortative mating (h = 1)
pathogen mutation rate	Ne	50	100	500	1000	5000	10 000
no pathogens		4.03 ± 0.02	4.96 ± 0.06	7.96 ± 0.12	10.23 ± 0.16	20.26 ± 0.26	29.81 ± 0.32
10−3		1.06 ± 0.03	1.24 ± 0.08	4.29 ± 0.27	10.06 ± 0.33	17.36 ± 0.38	31.15 ± 0.59
2 × 10−3		1.15 ± 0.06	1.41 ± 0.08	9.74 ± 0.26	10.74 ± 0.51	33.77 ± 0.41	51.70 ± 0.57
5 × 10−3		1.66 ± 0.12	3.09 ± 0.22	19.12 ± 0.23	29.76 ± 0.26	58.07 ± 0.38	88.65 ± 0.51