Figure 6.

Illustration of potential in vivo scenarios involving different pairs of kinesin motors. (a) Tug-of-war between kinesin-1 and -2, and kinesin-1 and -3 pairs. In both cases, kinesin-1 dominates the cargo transport, speeding up kinesin-2 and slowing down kinesin-3. (b) Roles of kinesin-5 and kinesin-7 in mitosis. Kinesin-5 generates the outward forces required to maintain pole-pole separation, whereas kinesin-7 tethers kinetochores to spindle microtubules. To see this figure in color, go online.