Figure 4.

The talin dimer can potentially adopt a collapse conformation if the two talin head domains are forced together by the ECM-bound integrins. ECM forces that would push two integrins together are simulated using MD models. The results show the C-terminus region of the talin dimer adopts a collapse conformation (bottom rendered figure). Flexibility in the C-terminus region allows the talin dimer to change its orientation in response to mechanical load. Shown in the top inset is a schematic of the source of a force moving two integrins toward each other. Shown in the bottom inset is a schematic of the possible orientation of the talin dimer if two integrins move toward each other. Each monomer is shown in green or blue. To see this figure in color, go online.