Table 1. Reported onco preventive agents in Oral carcinogenesis .

Phyto chemical	Mechanism of action	Preclinical studies	Clinical studies
Garlic	Anti proliferative Anti carcinogenic Natural killer cell activity	Meng et al17	Dorant et al18 Desai et al19 Kandil et al20
Flavonoids (Quercetin,Chalcone)	Anti proliferative	Hayashi et al23	Shie et al24 Fukai et al25 Sakagani et al26 Elattar et al 27
Xanthophylls ( Lutein, Zeaxanthin, Cryptoxanthin, Astaxanthin)	Anti oxidant Immuno modulator	Tanaka et al33	Dore J.E 34
Limonoids	Anti carcinogenic Anti mutagenic	Hasegawa et al36	Miller et al 36 Jacob et al 36 Ozaki et al 36
Spirulina fusiformis	Suppressed cell proliferation	Schwartz et al37	Mathew et al38 Bhavana et al39
Azadirachta indica	Ant lipidoperoxidative Antioxidant Antitumor activity	Subapriya et al40 Nagini et al41 Manikandan et al42	Hashmat et al40 Manoharan et al43
Curcumin Piperine	Antilipidoproliferative Antioxidant	Garg et al44	Tanaka et al45
Green tea	Antioxidant Antilipidoproliferative Stimulates detoxification cascade	Srinivas et al46 Lee et al46	Chandramohan et al47 Letchoumy et al47 Khafif et al48 Hsu et al5 Chen et al47 Kato et al46
Ferulic acid	Anticancer activity Antioxidant	Zhao et al49 Balakrishnan et al51	Gupta et al50 Toda et al5
Black Raspberries	Inhibits replication of human tumor cells		Casto et al52
Piperine	Modulates lipid peroxidation and antioxidant defense	-	Selvendiran et al53
Reservatrol	Antitumor property	-	Elatter et al 54
Oryza Sativa (Procatechuic acid &Costunolid)	Antioxidant	-	Suzuki et al55
Ocimum Sanctum	Anti tumor property	-	Karthikeyan et al40
S-allyl Cysteine	Elevation of hepatic glutathione and glutathione dependent enzymes	Balasenthil et al56	-
Bovine milk Lactoferrin	Inhibits DMBA induced genotoxicity inturn prevents Oral Cancer	Mohan KV et al57	-