Table 5.
Major radiation series comparing outcomes of anaplastic thyroid carcinoma.
| Author | Intent | Median radiation dose | Resection | Fractionation | Local control | Chemotherapy | Radiation duration | Median survival |
|---|---|---|---|---|---|---|---|---|
| Wang et al. [13] | Definitive | 60 Gy (45–66) | 61% | Once daily or bid | 94% (6 months) | No | 4–6 weeks | 11.1 months |
| Palliative | 40 Gy (split course) | 50% | Once daily | 65% (6 months) | 16% (prior to or during) | 4–6 weeks | 3.2 months | |
|
| ||||||||
| de Crevoisier et al. [14] | Definitive | 40 Gy (later boost to 50–55 Gy) | 71% | Bid | 68% (45 median FU) | Prior to and after | 3-4 weeks | 10 months (both arms) |
| Palliative | 40 Gy (later boost to 50–55 Gy) | 50% | Bid | 68% (45 median FU) | Prior to and after | 3-4 weeks | ||
|
| ||||||||
| Dumke et al. [15] | Both | 50 Gy (6–60.4) | 80% | Daily or bid | Unknown | 15% | Unknown | 5 months; if >50 Gy 10.5 months |
|
| ||||||||
| Stavas et al. | Definitive | 54 Gy (49.5–62.5) | 89% | Daily | 89% (at time of death) | 88% (concurrent) | 23.5 days (13–36) | 14.2 months |
| Palliative | 54 Gy (40–57) | 75% | Daily | 75% (at time of death) | 26 days (22–37) | 6.4 months | ||