Table 1.

Template for cost-minimization analysis based on various approaches

	Third-Party Approach	OSA Prediction Tool
Cost A: HST (US$)	174.00	[Sen(Prev) + (1 – Spec)(1 – Prev)] × 174
Cost B: In-lab PSG (US$)	—	[Prev(1 – Sen) + Spec(1 – Prev)] × 607
Cost C: In-lab PSG for patients with negative HST (US$)	(1 – Prev) × 607.00	[(1 – Prev) × (1 – Spec)] × 607.00
Total cost (US$)	Cost A + cost B + cost C	Cost A + cost B + cost C
Savings per patient with prediction tool (US$)	Total cost of OSA prediction tool less total cost of third-party approach
Total savings per year extrapolated to U.S. population	Savings per patient × 1,340,413*

Definition of abbreviations: HST, home sleep test; OSA, obstructive sleep apnea; PPV, positive predictive value for a given population was calculated as (Sen × Prev)/[(Sen × Prev) + (1 – Spec) × (1 – Prev)]; Prev, prevalence of OSA; PSG, polysomnography; Sen, sensitivity; Spec, specificity.

^*Based on 427 PSGs performed per 10,000 population/year.