Table 2.

Case series on the clinical course of allergic conjunctivitis after treatment with Restasis.

Patient	Ocular diagnosis	Age	Sex	Relevant allergies	Symptom onset before use of Restasis	Brief description on disease course	Eye drops in use before start of Restasis
1	LE VKC	6	M	Eczema and asthma	4 weeks	Presented with persistent epithelial defect and cobblestone giant papillae. Developed shield ulcer complicated by herpes simplex infection; ulcer healed with Restasis and acyclovir ointment with only faint corneal scars.	Patanol/ RT/PF
2	BE SAC	16	M	Nil	6 weeks	Left limbitis and BE papillae. Treated with Restasis BD, with recovery of the limbitis and improvement of symptoms.	Patanol/RT/Nadexin
3	BE AKC	10	M	Eczema and asthma	2 years	Started Restasis BD with improvement of symptoms.	Patanol/RT/FML
4	BE VKC	13	M	Allergic rhinitis	2 years	BE cobblestone giant papillae. Started on Restasis BD then tapered down to once daily on alternate days.	Patanol/ RT/FML/PF
5	BE PAC	12	F	Nil	1 year	Improvement in symptoms and decreased punctuate epithelial erosions and reduced conjunctival injection over the papillae with Restasis BD.	Patanol/FML
6	BE VKC	9	M	Nil	2 years	On and off limbitis and papillae. Used Restasis BD for 1 year with good control and 1 flare-up requiring QID. Now down to once daily dose on alternate days.	Patanol/RT/FML/PF
7	BE AKC	8	M	Eczema and asthma	2 years	BE giant papillae, with reduced conjunctival injection over the papillae Restasis BD	Patanol/RT/Nadexin/Lotemax
8	BE VKC	10	M	Nil	1.5 years	Giant papillae, with reduced conjunctival injection over the papillae with Restasis BD.	Patanol/FML
9	BE PAC	14	M	Asthma	3 years	Previously started with Restasis BD to TDS. Tapered down to once daily on alternate days after 5 months, with improvement of symptoms.	Patanol Lotemax
10	BE PAC	10	M	Allergic rhinitis	3 years	Reduced conjunctival injection over the papillae while on Restasis BD.	Patanol/FML
11	BE PAC	6	M	Allergic rhinitis	1 year	Reduced conjunctival injection over the papillae while on Restasis BD.	Patanol
12	BE AKC	16	M	Allergic rhinitis	16 months	Papillae with keratitis. Restasis BD used for 4 months, now down to once daily on alternate days, with recovery of the keratitis and improvement of symptoms.	Patanol/RT/FML
13	BE PAC	9	M	Nil	4 years	Reduced conjunctival injection over the papillae while on Restasis BD, later stopped due to financial reason.	Patanol/RT FML
14	BE VKC	12	M	Allergic rhinitis	2 months	Trantas dots and limbitis with papillae, now on Restasis BD, with recovery of the limbitis and improvement of symptoms.	Patanol/PF

BE = both eyes.

LE = left eye.

BD = twice daily.

TDS = three times daily.

Patanol = olopatadine hydrochloride ophthalmic solution 0.1%; Alcon Laboratories Inc., Fort Worth, Texas, USA.

RT = Refresh Tears (carboxymethylcellulose sodium 0.5%; Allergan Inc., Irvine, CA, USA).

PF = Pred Forte (prednisolone acetate 1%; Allergan Inc., Irvine, CA USA).

FML = fluorometholone (Allergan Inc., Irvine, CA, USA).

Nadexin = (dexamethasone 0.1% + chloramphenicol 0.5%; National Pharm Co. Ltd., Unit A-D 7/F Candy Novelty House 164 Wai Yip Street, Kowloon, Hong Kong).

Lotemax = (loteprednol etabonate ophthalmic 0.5%; Bausch & Lomb Inc., Tampa, Florida, USA).