Table 1.

Biological effects of SIRTs.

Substrates	Biological effects
FOXO, p53	Regulating cell cycle
Histones H1/H3/H4, Ku70	Alleviating cell apoptosis
FOXO1, PGC-1α	Alleviating glucose metabolism, lipid metabolism, and insulin secretion
FOXO1	Alleviating antioxidant
NF-κB	Alleviating inflammatory reaction

p53: protein 53; FOXO: forkhead-box transcription factor; PGC-1α: peroxisome proliferator-activated receptor-coactivator-1 α; NF-κB: nuclear factor-κB.