Table 2.
The Estimates of the Parameters from the Final Model (Equation 3)
| Parameters | Description | NONMEM |
Bootstrap |
||
|---|---|---|---|---|---|
| Estimate | RSE (%)* | Estimate | RSE (%) | ||
| Theta1 | Rate of change associated with age | 0.0137 | 16.1 | 0.0138 | 16.8 |
| Theta2 | Rate of change associated with height | 0.0169 | 2.20 | 0.0169 | 2.30 |
| Theta3 | Intercept among the ethnic groups | ||||
| White/Mexican American |
1.89 | 1.78 | 1.89 | 1.84 | |
| African American |
2.04 | 0.575 | 2.04 | 0.641 | |
| Others |
1.95 | 0.742 | 1.94 | 0.787 | |
| Thetadrugeffect | Drug effect of budesonide | 0.103 | 14.1 | 0.108 | 14.4 |
| Interindividual variability (SD) (shrinkage %)† | |||||
| Theta1 |
0.00722 (32.9) |
0.00723 |
|||
| Theta3 |
0.0912 (26.4) |
0.0915 |
|||
| Thetadrugeffect |
0.129 (67.3) |
0.123 |
|||
| Intraindividual variability (shrinkage %)‡ | |||||
| Proportional (CV%) |
5.91 (4.52) |
5.91 |
|||
| Additive (SD) | 0.0863 (4.52) | 0.0859 | |||
Definition of abbreviations: CV = coefficient of variation; NONMEM = nonlinear mixed-effects modeling; RSE = relative standard error.
*
Percent RSE (100% × standard error/estimate).
†
The SD across the subjects for each parameter.
‡
The CV and SD for the proportional and additive residual unexplained variability, respectively.