Table 2.
TT (n = 93) | CT (n = 68) | CC (n = 14) | P Value | Adjusted P Value* | |
---|---|---|---|---|---|
Additive model | |||||
Baseline IL1RA, pg/ml | 101.8 (84.5–146.6) | 120.1 (98.0–157.8) | 108.07 (87.2–141.9) | 0.12 | 0.073 |
IL1RA at 4 h, ng/ml† | 39.4 (21.5–63.1) | 50.9 (28.8–68.3) | 60.1 (14.8–75.5) | 0.064 | 0.008 |
IL1RA at 24 h, pg/ml | 232.8 (183.0–286.1) | 272.2 (221.7–338.1) | 232.2 (184.6–347.9) | 0.064 | 0.016 |
AUC IL1RA, ng/ml† | 51.4 (26.9–86.1) | 64.3 (38.2–90.8) | 74.5 (21.5–99.3) | 0.11 | 0.013 |
Dominant model | |
||||
Baseline IL1RA, pg/ml | 101.8 (84.5–146.6) | 117.3 (94.5–157.4) |
0.032 | 0.039 | |
IL1RA at 4 h, ng/ml† | 39.4 (21.5–63.1) | 52.2 (28.8–68.8) |
0.044 | 0.011 | |
IL1RA at 24 h, pg/ml | 232.8 (183.0–286.1) | 268.6 (216.8–338.8) |
0.009 | 0.015 | |
AUC IL1RA, ng/ml† | 51.4 (26.9–86.1) | 66.0 (37.9–92.4) | 0.075 | 0.026 |
Definition of abbreviation: AUC = area under the IL1RA curve.
Median (interquartile range) values are shown. Peak IL1RA response was at 4 hours post-LPS, and no shift in peak response was observed by genotype.
Given the low number of homozygous CC individuals, we collapsed CT and CC for a dominant model and analyzed by rank sum test or quantile regression adjusting for sex and body mass index.
Additive genetic models were tested by nonparametric trend and adjusted for sex, body mass index, and the first three components of genetic ancestry using quantile regression.
Change in scale to ng/ml for peak response and area under the IL1RA curve.