Table 2.

rs315952C Is Associated with Higher Baseline and Evoked IL1RA Post-LPS in European Ancestry Subjects

	TT (n = 93)	CT (n = 68)	CC (n = 14)	P Value	Adjusted P Value*
Additive model
Baseline IL1RA, pg/ml	101.8 (84.5–146.6)	120.1 (98.0–157.8)	108.07 (87.2–141.9)	0.12	0.073
IL1RA at 4 h, ng/ml†	39.4 (21.5–63.1)	50.9 (28.8–68.3)	60.1 (14.8–75.5)	0.064	0.008
IL1RA at 24 h, pg/ml	232.8 (183.0–286.1)	272.2 (221.7–338.1)	232.2 (184.6–347.9)	0.064	0.016
AUC IL1RA, ng/ml†	51.4 (26.9–86.1)	64.3 (38.2–90.8)	74.5 (21.5–99.3)	0.11	0.013
Dominant model
Baseline IL1RA, pg/ml	101.8 (84.5–146.6)	117.3 (94.5–157.4)		0.032	0.039
IL1RA at 4 h, ng/ml†	39.4 (21.5–63.1)	52.2 (28.8–68.8)		0.044	0.011
IL1RA at 24 h, pg/ml	232.8 (183.0–286.1)	268.6 (216.8–338.8)		0.009	0.015
AUC IL1RA, ng/ml†	51.4 (26.9–86.1)	66.0 (37.9–92.4)		0.075	0.026

Definition of abbreviation: AUC = area under the IL1RA curve.

Median (interquartile range) values are shown. Peak IL1RA response was at 4 hours post-LPS, and no shift in peak response was observed by genotype.

Given the low number of homozygous CC individuals, we collapsed CT and CC for a dominant model and analyzed by rank sum test or quantile regression adjusting for sex and body mass index.

^*Additive genetic models were tested by nonparametric trend and adjusted for sex, body mass index, and the first three components of genetic ancestry using quantile regression.

^†Change in scale to ng/ml for peak response and area under the IL1RA curve.