Table 3.
RNA-Seq Analysis at rs315952 (chr2:113890304) in Adipose Tissue for Heterozygous European Ancestry Subjects Indicates Strong Allelic Imbalance Favoring the C Allele
| Pre-LPS |
Post-LPS |
|||||||
|---|---|---|---|---|---|---|---|---|
| C Allele Counts | T Allele Counts | Proportion C Reads | P Value | C Allele Counts | T Allele Counts | Proportion C Reads | P Value | |
| A | 112 | 36 | 0.7568 | 4.18 × 10−10 | 358 | 91 | 0.7973 | 2.10 × 10−36 |
| B | 163 | 98 | 0.6245 | 5.74 × 10−5 | 289 | 198 | 0.5934 | 3.73 × 10−5 |
Of four European Ancestry subjects with adipose RNA and heterozygous (C/T) at rs315952, only subjects “A” and “B” met our filtering criteria of greater than or equal to 20 reads at this locus. The expected proportion of reads containing the C allele was 0.50, or 50%. Both subjects demonstrated strong allelic imbalance favoring the C allele (bold) both at rest and post-LPS.