Table 4.
Characteristics of the VASST Population with Available DNA for Genotyping
| 90-d Nonsurvivors (n = 287) | 90-d Survivors (n = 345) | P Value | |
|---|---|---|---|
| Age | 63.5 ± 16 | 57.7 ± 17 | <0.001 |
| Female | 118 (41.1%) | 144 (41.7%) | 0.72 |
| Ancestry | |||
| European | 232 (80.8%) | 298 (86.4%) | 0.065 |
| Asian | 24 (8.4%) | 17 (4.9%) | 0.10 |
| African | 9 (3.1%) | 5 (1.5%) | 0.18 |
| Site of infection | |||
| Lung | 129 (45.0%) | 147 (42.6%) | 0.56 |
| Abdomen | 73 (25.4%) | 97 (28.1%) | 0.39 |
| Other | 85 (29.6%) | 101 (29.3%) | |
| Infectious pathogen | |||
| Gram-positive bacteria | 79 (27.5%) | 110 (31.9%) | 0.32 |
| Gram-negative bacteria | 55 (19.2%) | 83 (24.1%) | 0.19 |
| Fungal or viral | 38 (13.2%) | 41 (11.9%) | 0.40 |
| Not identified | 131 (46.8%) | 143 (41.5%) | 0.18 |
| APACHE II | 28.0 ± 9 | 25.3 ± 7 | <0.001 |
| Randomized to vasopressin | 141 (49.1%) | 185 (53.6%) | 0.26 |
| Plasma available | 164 (57%) | 235 (68%) | 0.004 |
| Acute organ failure | |||
| Lung | 286 (99.7%) | 334 (96.8%) | 0.032 |
| Kidney | 246 (85.7%) | 161 (46.7%) | <0.001 |
| Liver | 236 (82.2%) | 121 (35.1%) | <0.001 |
| Coagulation | 269 (96.4%) | 289 (87.3%) | <0.001 |
| Central nervous system | 269 (93.7%) | 289 (83.8%) | <0.001 |
| Days alive and free of vasopressors, 28 d | 0 (0–9) | 23 (19–25) | <0.001 |
| Days alive and free of ventilator, 28 d | 0 (0–4) | 18 (10–23) | <0.001 |
Definition of abbreviations: APACHE = Acute Physiology and Chronic Health Evaluation; VASST = Vasopressin and Septic Shock Trial.
Variables are displayed as mean ± standard deviation, median (25–75 percentile range), or as number (percentage). Site of infection and infectious pathogen were not exclusive and thus the total may exceed 100%. Acute organ failures and organ failure–free days were defined by Brussels criteria within the first 28 days. Comparisons were made by t test, Wilcoxon rank sum test, chi-square, or Fisher exact test as appropriate. PF ratio = ratio of PaO2 to FiO2.