Table 1. Demographic and Clinical Features of the Fibrosis Groupsa,b.
| Factors | Mild Fibrosis (n = 66) | Advanced Fibrosis (n = 24) | P Value |
|---|---|---|---|
| Age, y | 54.08 ± 11.86 | 60.87 ± 10.88 | 0.01 |
| Females | 43 (65.1) | 12 (50) | 0.19 |
| SVR | 23 (34.8) | 6 (25) | 0.38 |
| Age ≥ 50 | 46 (69.6) | 21 (87.5) | 0.09 |
| Time since diagnosis, y | 5.52 ± 2.2 | 5.50 ± 1.81 | 0.68 |
| BMI, kg/m 2 | 24.27 ± 2.78 | 23.96 ± 2.83 | 0.84 |
| Hemoglobin, g/dL | 13.43 ± 1.79 | 13.87 ± 2.38 | 0.20 |
| MCV, mg/dL | 86.88 ± 7.60 | 88.42 ± 5.59 | 0.62 |
| Platelet, × 10 3 /mm 3 | 239.896 ± 77.026 | 161.375±62.645 | < 0.01 |
| Leucocyte, 10 9 /L | 6.7 ± 2.3 | 5.2 ± 1.8 | < 0.01 |
| Neutrophil, 10 9 /L | 3.8 ± 1.9 | 2.8 ± 1.1 | 0.02 |
| Lymphocyte, 10 9 /L | 2.2 ± 1.2 | 1.9 ± 0.6 | 0.24 |
| INR | 0.95 (0.82-1.14) | 0.99 (0.9-1.4) | 0.06 |
| Plasma fasting glucose, mg/dL | 103.56 ± 36.22 | 107.95 ± 30.82 | 0.11 |
| Diabetes mellitus | 10 (15.1) | 5 (20.8) | 0.52 |
| Hypertension | 24 (36.3) | 8 (33.3) | 0.79 |
| ALT, IU/L c | 36 (6-560) | 77.5 (24-607) | < 0.01 |
| AST, IU/L c | 29 (12-167) | 60.5 (30-879) | < 0.01 |
| ALP, IU/L | 91.29 ± 37.97 | 96.50 ± 32.11 | 0.30 |
| GGT, IU/L | 63.18 ± 28.33 | 77.25 ± 29.98 | 0.03 |
| Albumin, g/dL | 4.43 ± 0.49 | 4.35 ± 0.59 | 0.61 |
| Total cholesterol, mg/dL | 176.67 ± 38.75 | 159 ± 38.17 | 0.05 |
| HDL, mg/dL | 48.45 ± 12.92 | 45.63 ± 11.79 | 0.24 |
| LDL, mg/dL | 106.29 ± 34.90 | 93.79 ± 33.79 | 0.08 |
| Triglycerides, mg/dL | 103.24 ± 59.04 | 92.54 ± 39.33 | 0.46 |
| Na | 140.19 ± 2.72 | 140.58 ± 2.48 | 0.56 |
| K | 4.29 ± 0.44 | 4.32 ± 0.49 | 0.97 |
| Ca | 9.18 ± 0.70 | 9 ± 0.73 | 0.41 |
| ERα severity index, high expression | 39 (59) | 3 (12.5) | < 0.01 |
a Abbreviations: ALP, alkaline aminotransferase; ALT, alanine aminotransferase; AST, aspartate amino transferase, ; BMI, body mass index; ER, estrogen receptor; GGT, gamma glutamyl transaminase; HDL, high density lipoprotein; INR, international normalized ratio; LDL, low density lipoprotein; MCV, mean corpuscular volume; SVR, sustained virological response.
b Data are shown as mean ± SD. Categorical data are shown as n and frequencies (%).
c Data are shown as median (min-max) if distributions are skewed. Mild fibrosis group, < 2 fibrosis scores; advanced fibrosis group, ≥ 2 fibrosis scores.