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. 2014 Oct 30;5:225. doi: 10.3389/fneur.2014.00225

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Copyright © 2014 Archer, Warren, Jackson and Abbott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre- and post-operative EEG. Pre- and post-operative EEG in a 38-year-old male with LGS, a lesion, and intractable seizures since childhood. Prior to resection of a left frontal cortical dysplasia (arrowed), the patient suffered daily seizures. Pre-operative interictal EEG showed bursts of slow spike-and-wave (SSW) and generalized paroxysmal fast activity (GPFA). Day 3 post-operative EEG showed persistence of SSW, while day 30 EEG showed complete normalization, consistent with a winding down of the epileptic process. The patient is 2 years seizure free, consistent with LGS being potentially reversible. Re-printed with permission from Archer and colleagues (29).