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. 2014 Oct 30;5:526. doi: 10.3389/fimmu.2014.00526

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Copyright © 2014 Tomasello, Pollet, Vu Manh, Uzé and Dalod.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DCs play a central role in IFN-I orchestration of innate and adaptive immune responses. (A) IFN-I exert cell-intrinsic as well as indirect effects on a variety of immune cell populations. DC responses to IFN-I play a major role in promoting protective activation and functional polarization of other innate and adaptive immune cells, not only during viral infections but also in other physiopathological situations including cancer. (B) DC cell-intrinsic responses to IFN-I endow them to deliver appropriate signals for T cell priming and functional polarization. IFN-I can modulate all three types of signals delivered by DC to T cells: MHC-I/antigenic peptide complexes (), co-stimulation (), and cytokines (). This depends both on IFN-I-dependent transcriptional induction in DC of some of the corresponding genes and on IFN-I-dependent metabolic reprogramming of DC. (C) DC cell-intrinsic responses to IFN-I endow them to deliver appropriate signals, in particular IL-15 trans-presentation, for NK cell activation. See main text for further details.

Inline graphic — DCs play a central role in IFN-I orchestration of innate and adaptive immune responses. (A) IFN-I exert cell-intrinsic as well as indirect effects on a variety of immune cell populations. DC responses to IFN-I play a major role in promoting protective activation and functional polarization of other innate and adaptive immune cells, not only during viral infections but also in other physiopathological situations including cancer. (B) DC cell-intrinsic responses to IFN-I endow them to deliver appropriate signals for T cell priming and functional polarization. IFN-I can modulate all three types of signals delivered by DC to T cells: MHC-I/antigenic peptide complexes (), co-stimulation (), and cytokines (). This depends both on IFN-I-dependent transcriptional induction in DC of some of the corresponding genes and on IFN-I-dependent metabolic reprogramming of DC. (C) DC cell-intrinsic responses to IFN-I endow them to deliver appropriate signals, in particular IL-15 trans-presentation, for NK cell activation. See main text for further details.