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. 2014 Aug;3(3):65–74. doi: 10.5582/irdr.2014.01010

Table 4. Adverse effects of anti-HIV-1 reagents during chemotherapy.

Agents Adverse effects
AZT Bone marrow suppression, contraindication
d4T/ddI Peripheral nerve disorder/ileus (avoid with VCR)
Liver dysfunction (toxic for mitochondria)
Protease inhibitor (PI) RTV > IDV = APV > NFV> = SQV High blood level of anti-cancer agents (inhibition of CYP450-3A4)
NNRTI Efavirenz (EFV) Reduced function of anti-cancer agents (activate CYP450)
Nevirapine (NVP)
Abacavir (ABC) Hypersensitivity
Tenofovir (TDF) Renal dysfunction
HHS Vulnerability Disclosure