Table 4. Adverse effects of anti-HIV-1 reagents during chemotherapy.
Agents | Adverse effects |
---|---|
AZT | Bone marrow suppression, contraindication |
d4T/ddI | Peripheral nerve disorder/ileus (avoid with VCR) Liver dysfunction (toxic for mitochondria) |
Protease inhibitor (PI) RTV > IDV = APV > NFV> = SQV | High blood level of anti-cancer agents (inhibition of CYP450-3A4) |
NNRTI Efavirenz (EFV) | Reduced function of anti-cancer agents (activate CYP450) |
Nevirapine (NVP) | |
Abacavir (ABC) | Hypersensitivity |
Tenofovir (TDF) | Renal dysfunction |