Table 2.
Association between creatinine-adjusted urinary 1-OHPG concentration and risk of gastric cancer
| 1-OHPG (µmol/mol Cr) | Cases (N) | Controls (N) | Unadjusted | Adjusteda | Adjustedb |
|---|---|---|---|---|---|
|
| |||||
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
| Q1:< 0.12 | 28 | 76 | 1.00 | 1.00 | 1.00 |
| Q2: ≥ 0.12 to< 0.24 | 32 | 78 | 1.10 (0.61-1.99) | 1.15 (0.63-2.09) | 1.13 (0.59-2.14) |
| Q3: ≥ 0.24 to< 0.45 | 50 | 76 | 1.90 (1.06-3.41) | 1.93 (1.07-3.49) | 1.91 (1.02-3.60) |
| Q4: ≥ 0.45 | 43 | 76 | 1.56 (0.87-2.80) | 1.40 (0.77-2.54) | 1.34 (0.72-2.50) |
| P trend | 0.13 | 0.30 | 0.40 | ||
| Per 1-unit increase in 1-OHPGc | 1.07 (0.98-1.17) | 1.06 (0.97-1.16) | 1.05 (0.96-1.15) | ||
a
Adjusted for age, education, smoking status (ever/never), fruit intake, vegetable intake, and body mass index (BMI).
b
Same adjustments as above but additionally adjusted for H. pylori status within 423 subjects (141 cases and 282 controls).
c
A 1-unit increase was defined as half of the difference between the 25th and 75th percentiles for creatinine-adjusted 1-OHPG measurements among controls.