Table 2.
Multiple linear regression analysis on determinants of CML-AGE concentration among subcohort controls in the ATBC Study (N = 141)
| Factors | β (95% CI) | P |
|---|---|---|
| Age (years) | ||
| 55-59 vs. < 55 | -22.58 (-88.95 to 43.79) | 0.50 |
| ≥ 60 vs. < 55 | 5.28 (-78.63 to 89.18) | 0.90 |
| BMI (kg/m2) | ||
| 25-29.9 vs < 25 | 44.31 (-12.58 to 101.19) | 0.13 |
| ≥ 30 vs < 25 | 63.96 (-20.10 to 148.02) | 0.14 |
| Heart rate per minute | ||
| 68-76 vs. < 68 | 17.22 (-42.01 to 76.45) | 0.57 |
| ≥ 78 vs. < 68 | 61.93 (4.61 to 119.25) | 0.03 |
| Frequency of physical activity at leisure time/week | ||
| Moderate vs. low | -80.97 (-159.39 to -2.55) | 0.04 |
| High vs. low | -73.22 (-147.00 to 0.56) | 0.05 |
| Duration of smoking (years) | ||
| 32-38 vs. < 31 | -10.34 (-68.58 to 47.89) | 0.73 |
| ≥ 39 vs. < 31 | 37.62 (-38.84 to 114.09) | 0.33 |
| Alcohol intake (gram/per day) | ||
| 4.8-23.4 vs. < 4.8 | -30.16 (-86.76 to 26.45) | 0.29 |
| ≥ 23.5 vs. < 4.8 | -68.32 (-132.24 to -4.40) | 0.04 |
| Intake of vitamin E (mg/day) | ||
| 3.4-4.3 vs. < 3.4 | 13.02 (-43.03 to 69.07) | 0.65 |
| ≥ 4.4 vs. < 3.4 | -51.84 (-108.63 to 4.95) | 0.07 |
| Diastolic blood pressure (mm Hg) | -3.54 (-5.79 to -1.28) | 0.002 |
| Serum HDL* | 244.15 (136.48 to 351.82) | < 0.0001 |
| Serum insulin* | -32.67 (-78.80 to 13.46) | 0.16 |
| Serum sRAGE* | 199.87 (148.97 to 250.77) | < 0.0001 |
| RAGE rs2070600 (Gly82Ser vs. Ser82Ser) | 55.99 (-30.91 to 142.89) | 0.20 |
| DDOST rs640742 (Any G allele vs. TT) | -55.81 (-103.28 to -8.33) | 0.02 |
| R2 | 0.49 |
*
Logarithmically transformed (natural base) to meet assumption of linearity.