Table 3.
Multiple linear regression analysis on determinants of sRAGE concentrations (loge-transformed) among subcohort controls in the ATBC Study (N = 141)
| Factors | β coefficient (95% CI) | P |
|---|---|---|
| Age (years) | ||
| 55-59 vs. < 55 | -0.074 (-0.261 to 0.114) | 0.44 |
| ≥ 60 vs. < 55 | -0.252 (-0.484 to -0.021) | 0.03 |
| BMI (kg/m2) | ||
| 25-29.9 vs. < 25 | -0.101 (-0.257 to 0.054) | 0.20 |
| ≥ 30 vs. < 25 | -0.227 (-0.439 to -0.016) | 0.04 |
| Heart rate per minute | ||
| 68-76 vs. < 68 | -0.204 (-0.371 to -0.038) | 0.02 |
| ≥ 78 vs. < 68 | -0.127 (-0.292 to 0.037) | 0.13 |
| Duration of smoking (years) | ||
| 32-38 vs. < 31 | -0.134 (-0.297 to 0.029) | 0.11 |
| ≥ 39 vs. < 31 | -0.058 (-0.276~0.160) | 0.60 |
| Alcohol intake (gram/day) | ||
| 4.8-23.4 vs. < 4.8 | 0.168 (0.011 to 0.324) | 0.04 |
| ≥ 23.5 vs. < 4.8 | 0.156 (-0.026 to 0.338) | 0.09 |
| Intake of vitamin E (mg/day) | ||
| 3.4-4.3 vs. < 3.4 | 0.0096 (-0.150 to 0.169) | 0.90 |
| ≥ 4.4 vs. < 3.4 | 0.071 (-0.095 to 0.238) | 0.40 |
| Serum glucose (mg/dl) | ||
| 91-99 vs. ≤ 90 | -0.038 (-0.214 to 0.138) | 0.67 |
| > 99 vs. ≤ 99 | -0.096 (-0.268 to 0.077) | 0.28 |
| Diastolic blood pressure (mm Hg) | 0.011 (0.005 to 0.018) | 0.001 |
| Serum HDL* | -0.787 (-1.084 to -0.489) | < 0.0001 |
| Intake of sucrose* | 0.172 (0.029 to 0.315) | 0.02 |
| Serum CML-AGE (ng/ml) | 0.0015 (0.0011 to 0.0019) | < 0.0001 |
| RAGE rs2070600 (Gly82Ser vs. Ser82Ser) | -0.249 (-0.490 to -0.008) | 0.04 |
| R2 | 0.52 |
*
Logarithmically transformed (natural base) to meet assumption of linearity.