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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Cancer Res. 2014 Sep 26;74(20):5683–5689. doi: 10.1158/0008-5472.CAN-14-1171

Figure 2. DEAR1 Regulates Epithelial Plasticity by Inhibiting the TGFβ/SMAD3 pathway.

Figure 2

Normal DEAR1 expression promotes the fine regulation of SMAD3 and inhibits TGFβ-induced EMT-associated gene expression in HMECs, while loss of function of DEAR1 by genetic alterations, such as mutation, copy number alteration or loss of expression, results in loss of polarity, a dramatic increase of SMAD3 levels, and in the presence of TGFβ, the initiation of EMT.