Table 1.
Efficacy of individual and combined monoclonal antibody treatments in guinea pigs and nonhuman primates.
| Treatment groups, time of treatment | Dose (mg) | Mean time to death (days) | # Survivors / # Total | % Survival | % Weight loss | p-value, compared with | |
|---|---|---|---|---|---|---|---|
| cZMAb | MB-003 | ||||||
|
| |||||||
| Guinea pigs | - | - | |||||
| PBS, 3 dpi | N/A | 7.3 ± 0.5 | 0/4 | 0 | 9% | - | - |
| cZMAb, 3 dpi | 5 | 11.6 ± 1.8 | 1/6 | 17 | 7% | - | - |
| MB-003, 3 dpi | 5 | 8.2 ± 1.5 | 0/6 | 0 | 40% | - | - |
| ZMapp1, 3 dpi | 5 | 9.0 ± 0.0 | 4/6 | 67 | <5% | 0.190 | 0.0147 |
| ZMapp2, 3 dpi | 5 | 8.3 ± 0.6 | 3/6 | 50 | 8% | 0.634 | 0.0692 |
| ZMapp3, 3 dpi | 5 | 8.6 ± 1.1 | 1/6 | 17 | 9% | 0.224 | 0.411 |
| c13C6, 1 dpi | 5 | 8.4 ± 1.7 | 1/6 | 17 | 9% | - | - |
| h13F6, 1 dpi | 5 | 10.2 ± 1.8 | 1/6 | 17 | 21% | - | - |
| c6D8, 1 dpi | 5 | 10.5 ± 2.2 | 0/6 | 0 | 38% | - | - |
| Treatment groups, time of treatment | Dose (mg/kg) | Mean time to death (days) | # Survivors / # Total | % Survival |
|---|---|---|---|---|
|
| ||||
| Nonhuman primates | ||||
| PBS, 1 dpi | N/A | 8.4 ± 1.9 | 0/1 | 0 |
| MB-003, 1 dpi | 50 | 14.0 ± 2.8 | 1/3 | 33 |
| c13C6, 1 dpi | 50 | 9.0 ± 1.4 | 1/3 | 33 |
| h13F6, 1 dpi | 50 | 9.0 ± 2.0 | 0/3 | 0 |
| c6D8, 1 dpi | 50 | 9.7 ± 0.6 | 0/3 | 0 |