Table 2.
Clinical findings of EBOV-infected NHPs from 1 to 27 dpi.
| Animal ID | Treatment group | Clinical findings | Outcome | ||||
|---|---|---|---|---|---|---|---|
| Body temperature | Rash | White blood cells | Platelets | Biochemistry | |||
| A1 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Fever (6, 9, 14 dpi) | Thrombocytopenia (6, 9 dpi) | ALT↑ (9, 14 dpi), TBIL↑ (9 dpi), PHOS↓ (6 dpi) | Survived | ||
| A2 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Fever (3 dpi) | Leukocytosis (3 dpi) | CRE↓ (14 dpi) | Survived | ||
| A3 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Fever (3 dpi) | Leukocytosis (3 dpi) | Thrombocytopenia (6 dpi) | Survived | ||
| A4 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Leukocytopenia (9 dpi) | Thrombocytopenia (3, 6, 14, 21, 27 dpi) | Survived | |||
| A5 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Fever (3, 6, 9 dpi) | Leukocytopenia (9 dpi) | Thrombocytopenia (3, 21 dpi) | Survived | ||
| A6 | 50 mg/kg c13C6+c2G4+m4G7, 3 dpi | Fever (3 dpi) | Survived | ||||
| B1 | 50 mg/kg ZMapp2, 3 dpi | Fever (3, 14, 21 dpi) | Leukocytopenia (6, 14, 21, 27 dpi) | Thrombocytopenia (6 dpi) | Survived | ||
| B2 | 50 mg/kg ZMapp2, 3 dpi | Fever (3, 6 dpi) | Thrombocytopenia (6, 9 dpi) | Survived | |||
| B3 | 50 mg/kg ZMapp2, 3 dpi | Fever (3, 6 dpi), Hypothermia (9 dpi) | Severe rash (9 dpi) | Thrombocytopenia (6, 9 dpi) | ALT↑↑↑ (9 dpi), TBIL↑↑ (9 dpi), BUN↑↑↑ (9 dpi), CRE↑↑↑ (9 dpi), GLU↓↓ (9 dpi) | Died, 9 dpi | |
| B4 | 50 mg/kg ZMapp2, 3 dpi | Fever (3, 6 dpi) | Leukocytopenia (6 dpi) | Thrombocytopenia (6, 27 dpi) | Survived | ||
| B5 | 50 mg/kg ZMapp2, 3 dpi | Fever (3, 6, 14, 21 dpi) | Leukocytosis (3 dpi) | Thrombocytopenia (3, 6 dpi) | Survived | ||
| B6 | 50 mg/kg ZMapp2, 3 dpi | Fever (3 dpi) | Leukocytosis (3 dpi), Leukocytopenia (6, 9, 14, 21, 27 dpi) | Thrombocytopenia (6 dpi) | PHOS↓ (3 dpi), CRE↓ (27 dpi) | Survived | |
| C1 | PBS, 3 dpi | Moderate rash (6 dpi), Severe rash (7 dpi) | Leukocytosis (3 dpi) | Thrombocytopenia (6, 7 dpi) | ALB↓ (7 dpi), ALT↑ (7 dpi), BUN↑ (7 dpi) | Died, 7 dpi | |
| C2 | Control mAb, 3 dpi | Severe rash (6 dpi) | Leukocytopenia (6, 7 dpi) | Thrombocytopenia (6, 7 dpi) | ALP↑ (3 dpi), ALT↑↑↑ (6 dpi), BUN↑ (6 dpi), CRE↑↑↑ (6 dpi) | Died, 6 dpi | |
Hypothermia was defined as below 35°C. Fever was defined as >1.0°C higher than baseline. Mild rash was defined as focal areas of petechiae covering <10% of the skin, moderate rash as areas of petechiae covering 10 to 40% of the skin, and severe rash as areas of petechiae and/or ecchymosis covering >40% of the skin. Leukocytopenia and thrombocytopenia were defined as a >30% decrease in numbers of WBCs and platelets, respectively. Leukocytosis and thrombocytosis were defined as a twofold or greater increase in numbers of WBCs and platelets over baseline, where WBC count >11.000. ↑, two- to threefold increase; ↑↑, four- to fivefold increase; ↑↑↑, greater than fivefold increase; ↓, two- to threefold decrease; ↓↓, four- to fivefold decrease; ↓↓↓, greater than fivefold decrease. ALB, albumin; AMY, amylase; TBIL, total bilirubin; BUN, blood urea nitrogen; PHOS, phosphate; CRE, creatinine; GLU, glucose; GLOB, globulin.