Table 3.
Clinical findings of EBOV-infected NHPs from 1 to 28 dpi.
| Animal ID | Treatment group | Clinical findings | Outcome | ||||
|---|---|---|---|---|---|---|---|
| Body temperature | Rash | White blood cells | Platelets | Biochemistry | |||
| D1 | 50 mg/kg ZMapp™, 3 dpi | Fever (3, 6, 14, 21 dpi) | Leukocytosis (3, 6, 21 dpi) | Thrombocytopenia (3, 6, 9, 14, 21 dpi) | ALB↓ (14, 21 dpi), ALP↓ (9, 14, 21, 28 dpi), AMY↓ (9 dpi), GLOB↑ (21, 28 dpi) | Survived | |
| D2 | 50 mg/kg ZMapp™, 3 dpi | Leukocytopenia (21, 28 dpi) | Thrombocytopenia (28 dpi) | PHOS↓ (9 dpi) | Survived | ||
| D3 | 50 mg/kg ZMapp™, 3 dpi | Fever (3 dpi) | Leukocytosis (3, 14 dpi) | Thrombocytopenia (3, 21, 28 dpi) | ALT↓ (6 dpi) | Survived | |
| D4 | 50 mg/kg ZMapp™, 3 dpi | Leukocytopenia (14 dpi) | Thrombocytopenia (14, 21 dpi) | ALT↓ (9 dpi), CRE↑ (14 dpi) | Survived | ||
| D5 | 50 mg/kg ZMapp™, 3 dpi | Fever (3 dpi) | Leukocytopenia (21, 28 dpi) | Thrombocytopenia (6, 9 dpi) | ALB↓ (9 dpi), BUN↓ (3, 6, 14, 21, 28 dpi) | Survived | |
| D6 | 50 mg/kg ZMapp™, 3 dpi | Thrombocytopenia (6 dpi) | Survived | ||||
| E1 | 50 mg/kg ZMapp™, 4 dpi | Thrombocytopenia (4, 7, 21 dpi) | AMY↓↓ (4, 21 dpi), AMY↓ (7, 10, 14 dpi), CRE↓ (21, 28 dpi) | Survived | |||
| E2 | 50 mg/kg ZMapp™, 4 dpi | Fever (4 dpi) | Leukocytosis (4, 10 dpi) | Thrombocytopenia (4, 7, 10, 21 dpi) | ALT ↓↓ (4 dpi), GLU↑ (4 dpi) | Survived | |
| E3 | 50 mg/kg ZMapp™, 4 dpi | Fever (4 dpi) | Leukocytosis (4, 10 dpi) | Thrombocytopenia (7, 10, 14 dpi) | CRE↓ (14 dpi) | Survived | |
| E4 | 50 mg/kg ZMapp™, 4 dpi | Severe rash (5, 6, 7, 8 dpi), Mild rash (9 dpi) | Leukocytosis (10, 14, 21, 28 dpi) | Thrombocytopenia (4, 7, 10, 14 dpi) | ALP↑ (7, 10, 14 dpi), ALT ↑↑↑ (7 dpi), ALT ↑↑ (10 dpi), AMY↓ (4, 7, 10 dpi), TBIL↑↑↑ (7 dpi), TBIL↑ (10, 14 dpi), PHOS↓ (7, 10 dpi), K+↓ (4 dpi) | Survived | |
| E5 | 50 mg/kg ZMapp™, 4 dpi | Fever (7 dpi) | Leukocytosis (4 dpi) | Thrombocytopenia (4, 7, 10, 14 dpi) | ALT↑ (7 dpi), AMY↓ (4, 7 dpi), PHOS↓ (10 dpi) | Survived | |
| E6 | 50 mg/kg ZMapp™, 4 dpi | Fever (4 dpi) | Mild rash (7, 8, 9 dpi) | Leukocytosis (4, 10, 14 dpi) | Thrombocytopenia (4, 7, 10, 14 dpi) | ALP↑ (7, 10 dpi), ALT ↑↑↑ (7, 10, 14 dpi), AMY↓ (7, 10 dpi), TBIL↑↑ (7 dpi), TBIL↑↑↑ (10 dpi), TBIL↑ (14 dpi), PHOS↓ (7 dpi), GLOB↑ (21 dpi) | Survived |
| F1 | 50 mg/kg ZMapp™, 5 dpi | Leukocytosis (11 dpi) | Thrombocytopenia (3, 5, 8, 11 dpi) | AMY↓ (5 dpi), PHOS↓ (11 dpi), CRE↓ (28 dpi) | Survived | ||
| F2 | 50 mg/kg ZMapp™, 5 dpi | Fever (3, 5 dpi) | Mild rash (8 dpi) | Leukocytosis (3, 5, 11 dpi) | Thrombocytopenia (3, 5, 8, 11, 14, 21 dpi) | PHOS↓ (11 dpi), CRE↓↓ (11 dpi) | Survived |
| F3 | 50 mg/kg ZMapp™, 5 dpi | Leukocytopenia (8 dpi), Leukocytosis (3 dpi) | Thrombocytopenia (5, 8, 11, 21 dpi | ALT↑ (8 dpi), CRE↓↓ (14 dpi) | Survived | ||
| F4 | 50 mg/kg ZMapp™, 5 dpi | Fever (3, 5 dpi) | Leukocytopenia (8 dpi) | Thrombocytopenia (5, 8, 11, 28 dpi) | PHOS↓ (8 dpi) | Survived | |
| F5 | 50 mg/kg ZMapp™, 5 dpi | Fever (3 dpi) | Leukocytosis (3, 11, 14 dpi) | Thrombocytopenia (5, 8, 11 dpi) | PHOS↓ (5, 8 dpi), CRE↓ (8, 11, 21, 28 dpi) | Survived | |
| F6 | 50 mg/kg ZMapp™, 5 dpi | Fever (3 dpi) | Leukocytopenia (8, 21, 28 dpi) | Thrombocytopenia (8, 11, 21 dpi) | PHOS↓ (5, 8, 11 dpi), GLU↑ (5 dpi) | Survived | |
| G1 | PBS, 4 dpi | Severe rash (4 dpi) | Leukocytopenia (4 dpi) | Thrombocytopenia (4 dpi) | AMY↓ (4 dpi) | Died, 4 dpi | |
| G2 | Control mAb, 4 dpi | Severe rash (8 dpi) | Leukocytopenia (7, 8 dpi) | Thrombocytopenia (4, 7, 8 dpi) | ALP↑ (8 dpi), ALT↑ (7 dpi), ALT ↑↑↑ (8 dpi), CRE↑ (8 dpi) | Died, 8 dpi | |
| G3 | PBS, 4 dpi | Fever (4, 8 dpi) | Severe rash (8 dpi) | Leukocytopenia (7, 8 dpi) | Thrombocytopenia (4, 7, 8 dpi) | ALP↑ (8 dpi), ALT↑ (7, 8 dpi), AMY↓ (7 dpi), AMY ↓↓ (8 dpi), TBIL↑ (8 dpi), PHOS↓ (7 dpi) | Died, 8 dpi |
Hypothermia was defined as below 35°C. Fever was defined as >1.0°C higher than baseline. Mild rash was defined as focal areas of petechiae covering <10% of the skin, moderate rash was defined as areas of petechiae covering 10 to 40% of the skin, and severe rash was defined as areas of petechiae and/or ecchymosis covering >40% of the skin. Leukocytopenia and thrombocytopenia were defined as a >30% decrease in the numbers of WBCs and platelets, respectively. Leukocytosis and thrombocytosis were defined as a twofold or greater increase in numbers of WBCs and platelets above baseline, where WBC counts are greater than 11.0. ↑, two- to threefold increase; ↑↑, four- to fivefold increase; ↑↑↑, greater than fivefold increase; ↓, two- to threefold decrease; ↓↓, four- to fivefold decrease; ↓↓↓, greater than fivefold decrease. ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMY, amylase; TBIL, total bilirubin; BUN, blood urea nitrogen; PHOS, phosphate; CRE, creatinine; GLU, glucose; K+, potassium; GLOB, globulin.