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. Author manuscript; available in PMC: 2014 Oct 30.
Published in final edited form as: Chembiochem. 2009 Nov 23;10(17):2721–2724. doi: 10.1002/cbic.200900552

Figure 2.

Figure 2

Compound 1 inhibits KIX–KID interaction in living cells. A) Forskolin dose-dependently stimulates KIX–KID interaction in cells. HEK293T cells were transfected with RLucC–KIX and KID–RLucN. The transfected cells were then treated with increasing concentrations of forskolin for 2 h. The Renilla luciferase activity was then measured by adding coelenterazine to the cells. B) Compound 1 inhibits KIX–KID interaction in cells. Same as in (A), except that the transfected cells were pretreated with increasing concentrations of 1 (▲) or 3 (●) before the addition of forskolin (2.5 μm).