A. qRT-PCR of proposed osteoblastic-associated factors TNFRSF11B, BMP7, EDN1, and EMID1 in osteoblastic (white squares) and osteolytic (black circles) PCa metastases. B. qRT-PCR of proposed osteolytic-associated factors MMP12, SFRP1, SOST, and DKK1 in osteoblastic (white squares) and osteolytic (black circles) PCa metastases. All samples are normalized against β-actin. * indicates significant difference with a p-value of p < 0.05.