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. 2014 Aug 12;10(5):2358–2364. doi: 10.3892/mmr.2014.2485

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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RNA interference-mediated inhibition of DSC2 affects desmosome protein expression and localization. (A) Immunofluorescence analysis of the subcellular localizations of the DSG2 and PKP2 proteins (magnification, ×400). Of note, knocking down the expression of DSC2 caused reduced DSG2 and PKP2 membrane localization (white arrows). (B) Western blot analyses of DSG2 and PKP2 protein expression in the DSC2-specific siRNA or control-transfected SHEEC cells. β-actin served as a loading control. DSC2, desmocollin-2; siDSC2, DSC2-specific siRNA; DSG2, desmoglein-2; PKP2, plakophilin-2.