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Diagram shows the signaling pathways involving the effects of MS-153 in upregulation of GLT1. Under an unknown mechanism, MS-153 administration may increase GLT1 transcription through phosphorylation by IkB kinase of the IkB-p50–p65 complex, which dissociated to p50–p65 and IkB. The nuclear translocation of p50–p65 can lead to increased transcription of GLT1.
