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5-FU sensitivity (IC50) following SB203580 treatment. The HCT116 and HCT15 cells with high levels of HSP27 expression exhibited higher 5-FU IC50 values than the HT29 cells with a low level of HSP27 expression in the control. SB203580 treatment significantly reduced the 5-FU IC50 values in the HCT116 and HCT15 cells. (A) HCT116; (B) HCT15; and (C) HT29. IC50, half maximal inhibitory concentration; HSP, heat shock protein; 5-FU, 5-fluorouracil; SB, SB203580.
