Figure 4.

TNFR1 expression levels in leukocytes of patients with severe trauma. In the control patients, TNFR1 was highly expressed on neutrophils, moderately on monocytes and marginally on lymphocytes. Traumatic injury induced increased expression levels of the receptor, particularly on lymphocytes and monocytes. The blood samples were obtained within 2 h of injury, and surface expression levels of the receptor were assessed by flow cytometry. Values indicate mean fluorescence intensity and are presented as the mean ± SD, n=20 per group. ^*P<0.01, compared with the healthy controls. TNFR1, tumor necrosis factor receptor 1; L/M/H-ISS, low/medium/high injury severity score.