Figure 2.

Combined effects of puerarin and 5-FU on the hepatocellular carcinoma cell line, SMMC7721. The CI values were determined using the method described by Chou and Talalay (18,19). CI=1, cumulative effect; CI<1, synergistic effect; and CI>1, antagonistic effect. The CI values for puerarin and 5-FU were <1 when the fractions affected were between 0.2555 and 0.7420. Thus, at specific concentrations, puerarin and 5-FU exhibit a synergistic inhibitory effect on the proliferation of SMMC7721 cells. 5-FU, 5-fluorouracil; CI, combination index.