Figure 2.

Application potential of different bacteria for oral squamous cell carcinoma (OSCC) tumor-targeted therapy. (A) By retrieving and analyzing studies of human bacterial normal flora in the mouth and the bacteria used in tumor-targeting therapy, Bifidobacterium, Streptococcus, Caulobacter and Clostridium were found to have potential as OSCC tumor-targeting therapy bacterial vectors. (B) By retrieving and analyzing studies of human bacterial normal flora [colony-forming units (CFU)/ml≥10⁵] in the mouth and the bacteria used in tumor-targeting therapy, Bifidobacterium and Streptococcus exhibited greater application potential in OSCC tumor-targeting therapy. (C) Furthermore, by retrieving and analyzing the studies of the genera most prevalent in the OSCC library and the bacteria used in tumor-targeting therapy, Streptococcus was found to exhibit the most therapeutic potential as an OSCC tumor-targeted therapeutic bacterial vector. (D) By retrieving and analyzing the three species of oral cancer diagnostic markers and the bacteria used in tumor-targeting therapy, Streptococcus exhibited the most therapeutic potential in OSCC tumor-targeted therapy.