Figure 1.

Associations of fetal blood flow, fetal combined kidney volume, and childhood kidney volume with childhood eGFR (n=613). Bars represent regression coefficients (95% CIs) based on multiple regression models and reflect the associations of fetal blood flow and kidney volume (A), fetal blood flow and childhood kidney volume (B), and fetal and childhood kidney volume (C) (tertiles) with childhood eGFR. Models are adjusted for maternal age, parity, education level, prepregnancy body mass index, smoking status during pregnancy, folic acid use during pregnancy, maternal pregnancy complications (hypertension, preeclampsia), gestational age at third trimester measurement, third trimester estimated fetal weight, child sex, gestational age, and gestational age–adjusted birth weight, and current age. P<0.01 for the interaction between fetal blood flow and fetal combined kidney volume for the association with childhood eGFR. The P value for the interaction between fetal blood flow and childhood combined kidney volume and for interaction between fetal combined kidney volume and childhood combined kidney volume is not significant.