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. 2014 Apr 10;25(11):2499–2510. doi: 10.1681/ASN.2013070786

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Copyright © 2014 by the American Society of Nephrology

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Figure 3. — Bone marrow crosstransplantation studies in FHH and Nr4a1^−/− rats. (A and B) Proteinuria and renal function in FHH or Nr4a1^−/− rats undergoing reciprocal bone marrow transplantation. Recipient animals are irradiated (irr) at week 8, provided bone marrow (bm) isolated from donor animals, and evaluated for proteinuria and/or renal function markers at weeks 12, 16, 20, and 24. (C) Morphometric analysis of tubulointerstitial injury (fibrosis) and representative Masson’s trichrome images. (D) Quantification of tubulointerstitial macrophage infiltration and immunohistochemistry kidney images from FHH and Nr4a1^−/− bone marrow transplant animals at week 24. *P<0.05 versus control groups; ^†P<0.05 versus other groups. BW, body weight; KW, kidney weight.