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. 2014 Sep 2;25(11):2584–2595. doi: 10.1681/ASN.2013080896

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Copyright © 2014 by the American Society of Nephrology

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Figure 1. — Sall1 deletion depletes nephron progenitors and their derivatives. (A) Kidneys in a newborn control mouse (P0). ad, Adrenal gland; bl, bladder; kid, kidney; ov, ovary. (B) Kidney size is reduced in a newborn Six2GFPCre;Sall1^flox/flox mouse (P0). te, Testis. (C and D) Hematoxylin-eosin staining of newborn kidneys. Severe dysgenesis is observed in the Six2GFPCre;Sall1^flox/flox mouse kidney. Scale bar, 100 μm. (E–N) Immunostaining for Six2 (nephron progenitor), Wt1 (nephron progenitor and podocyte), LTL (proximal renal tubule), THP (the loop of Henle), and NCC (distal renal tubule). Development of the nephron components is significantly impaired in the Six2GFPCre;Sall1^flox/flox mouse kidney.